Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth
نویسندگان
چکیده
منابع مشابه
Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth.
Raf inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent activating mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were sensitive to a novel series of Raf inhibitors (e.g., (V600E)B-Raf A375, IC(50) on cells = 2 nmol/L; ED(50) on tumor xenografts = 1.3 mg/kg). However, in cells and tumors with wild-type B-...
متن کاملcular Medicine in Practice ctive and Potent Raf Inhibitors Paradoxically Stimulate Ther mal Cell Proliferation and Tumor Growth
ownload inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent ting mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were sento a novel series of Raf inhibitors (e.g., B-Raf A375, IC50 on cells = 2 nmol/L; ED50 on tumor rafts = 1.3 mg/kg). However, in cells and tumors with wild-type B-Raf, exposure to Raf inhi...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2010
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-10-0181