Selection of Drug-Resistant Feline Immunodeficiency Virus (FIV) Encoding FIV/HIV Chimeric Protease in the Presence of HIV-Specific Protease Inhibitors

Resistance mechanism of human immunodeficiency virus type-1 protease to inhibitors: A molecular dynamic approach

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors comprise an important class of drugs used in HIV treatments. However, mutations of protease genes accelerated by low fidelity of reverse transcriptase yield drug resistant mutants of reduced affinities for the inhibitors. This problem is considered to be a serious barrier against HIV treatment for the foreseeable future. In this st...

Screening Efficacy of Available HIV Protease Inhibitors on COVID-19 Protease

Background and Aim: Advent of COVID-19 attracted the attentions of researchers to develop drugs for its treatment. Besides efforts on developing new drugs, screening available drugs for efficacy on COVID-19 could be an urgent action of initiating its pharmacotherapy. In this study, efficacy of HIV protease inhibitors on COVID-19 protease has been examined. Methods: Molecular docking based scree...

Seroprevalence of Feline Immunodeficiency Virus (FIV) among Client-owned Cats in Ahvaz, Southwestern of Iran

The present study was conducted to detect prevalence and risk factors for retrovirus infection of infected cats in a cat population in Iran, by evaluation of 238 client-owned cats of different ages that were tested for the presence of FIV antibodies. The cats were selected from those referring to Veterinary Hospital of Ahvaz University, southwestern Iran from December 2007 to June 2010. Classif...

Pharmacological Inhibition of Feline Immunodeficiency Virus (FIV)

Feline immunodeficiency virus (FIV) is a member of the retroviridae family of viruses and causes an acquired immunodeficiency syndrome (AIDS) in domestic and non-domestic cats worldwide. Genome organization of FIV and clinical characteristics of the disease caused by the virus are similar to those of human immunodeficiency virus (HIV). Both viruses infect T lymphocytes, monocytes and macrophage...

New HIV protease inhibitors for drug-resistant viruses