Selectins with a catch
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چکیده
منابع مشابه
Selectins with a catch
Small minerals make strong bones Selectins with a catch ot content simply with a good fit, evolution has apparently designed adhesion molecules that stick optimally only when tugged upon. This property, may stop leukocytes and platelets from lingering in stagnant backwaters in the blood where there is little or no flow. Blood is a medium dominated by flow and shear forces. " If you think flow i...
متن کاملDynamic competition between catch and slip bonds in selectins bound to ligands.
Atomic force measurements of unbinding rates (or off-rates) of ligands bound to a class of cell adhesion molecules from the selectin family show a transition from catch to slip bonds as the value of external force (f) is increased. At low forces (<10 pN), the unbinding rates decrease (catch regime), while, at high forces, the rates increase in accord with the Bell model (slip regime). The energ...
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The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
متن کاملSelectins promote tumor metastasis.
Cancer metastasis is facilitated by cell-cell interactions between cancer cells and endothelial cells in distant tissues. In addition, cancer cell interactions with platelets and leukocytes contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Selectins are carbohydrate-binding molecules that bind to sialylated, fucosylated glycan structures, and are fo...
متن کاملSelectins: a family of adhesion receptors.
Recent data have shown that a group of cell surface proteins, originally studied independently as lymphocyte homing receptors or as activation-induced surface proteins of platelets and/or endothelial cells (Stoolman, 1989) are structurally related. Each is an integral membrane protein with an N-terminal, C-type lectin domain followed by an EGF-like module, multiple copies of the consensus repea...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1614rr2