Selectins and glycosyltransferases in leukocyte rollingin vivo
نویسندگان
چکیده
منابع مشابه
Selectins: critical mediators of leukocyte recruitment.
Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will e...
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The selectins are a family of cell–cell adhesion proteins that participate in leukocyte–endothelial and leukocyte– platelet interactions [1–4]. The family consists of three members: P-selectin, expressed on activated endothelium and platelets; E-selectin, expressed on activated endothelium; and L-selectin, expressed on circulating leukocytes (Fig. 1). During the process of leukocyte emigration ...
متن کاملPolymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins.
The roles of selectin adhesion molecules (P- and L-selectin) and their counterreceptor sialyl Lewisx were investigated in polymorphonuclear leukocyte (PMN)-induced cat coronary vasocontraction and endothelial dysfunction. Unstimulated autologous PMNs (10(6) cells/mL) were added to organ chambers containing cat coronary artery rings stimulated with either thrombin (2 U/mL) or hydrogen peroxide (...
متن کاملProkaryotic peptides that block leukocyte adherence to selectins
Pertussis toxin binds target cells through the carbohydrate recognition properties of two subunits, S2 and S3, which share amino acid sequence similarity with the lectin domains of the eukaryotic selectin family. Selectins appear on inflamed endothelial cells and promote rolling of leukocytes by reversibly binding carbohydrates. S2, S3, and synthetic peptides representing their carbohydrate rec...
متن کاملLeukocyte Rolling In Vivo
The influence of platelet-vessel wall interactions on leukocyte rolling was investigated in rabbit mesenteric venules (diameter, 21-40 gm) using intravital videomicroscopy. Puncture of the wall with glass micropipettes (tip, 6-8 ,um) evoked the formation of a thrombus in all venules. In most vessels, emboli were produced as well. The rolling of leukocytes (i.e., their movement along the vessel ...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2006
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2006.05437.x