Selected environmental risk factors and congenital heart defects

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Selected environmental exposures and risk of neural tube defects

With a birth prevalence of 1 in 1000, neural tube defects (NTD)s contribute considerably to morbidity and healthcare costs. Known genetic and environmental (noninherited) risk factors for NTDs account for a small portion of risk, suggesting unidentified risk factors. In animal studies, maternal alcohol and pesticide exposures, independently, led to excess neural cell death, resulting in too few...

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Patterns of Potential Human Progress Volume 3: Improving Global Health 90 People have recognized the relationship between the state of the environment and human health for many years. Dr. John Snow, considered the father of modern epidemiology, is best remembered for linking the 1854 London cholera outbreak to the local drinking water supply (McMichael 2001). The smog episodes in Donora, Pennsy...

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Paternal Occupational Exposure to Solvents and The Risk of Congenital Heart Defects in Children Using Job Exposure Matrix

Background and aims: Currently, as a result of research on laboratory animals, abundant information has been obtained on the impact of various environmental factors on the occurrence of congenital malformations, but there is still no comprehensive information on the causes of congenital heart malformations (CHD) in human populations. Congenital heart defects (CHDs) constitute the major class of...

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Noninherited risk factors and congenital cardiovascular defects: current knowledge.

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W HILE REMARKABLE advances have been made during the past two decades in the diagnosis and medical and surgical management of congenital heart disease, little progress has been made in understanding etiology. With the hope that new information might be gained about environmental factors, genetic constitution, and their interplay, we have directed our attention to a group of families in which th...

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ژورنال

عنوان ژورنال: Medicina

سال: 2008

ISSN: 1648-9144

DOI: 10.3390/medicina44110104