Seeing and believing: recent advances in imaging cell-cell interactions

Seeing and believing: recent advances in imaging cell-cell interactions

Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution op...

Recent Advances in T Cell Signaling in Aging

The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...

Protein interactions: is seeing believing?

4 Savage, S.A. and Chanock, S.J. (2006) Genetic association studies in cancer: good, bad or no longer ugly? Hum. Genomics 2, 415–421 5 Kornberg, A. (2003) Ten commandments of enzymology, amended. Trends Biochem. Sci. 28, 515–517 6 Beltrao, P. et al. (2007) Structures in systems biology. Curr. Opin. Struct. Biol. 17, 378–384 7 Zhao, Z. and Zhang, F. (2006) Sequence context analysis of 8.2 millio...

Seeing is believing: Updates in retinal imaging.

n w i c C w f It is truly not easy to imagine a subspecialty in ophthalmolgy that has so dramatically changed its appearance as the ield of retina and retinal diseases. More than a decade ago urgical retina was mostly large gauge and time consuming hile medical retina used invasive diagnostics with limited reatment options. As the advances in retinal therapeutics ere on its way, the most dramat...

Thallium 201 myocardial imaging. Seeing is believing--believing what?