Sedative-hypnotic activity of cinnamic acid derivatives in mice
نویسندگان
چکیده
منابع مشابه
Multifunctional Cinnamic Acid Derivatives.
Our research to discover potential new multitarget agents led to the synthesis of 10 novel derivatives of cinnamic acids and propranolol, atenolol, 1-adamantanol, naphth-1-ol, and (benzylamino) ethan-1-ol. The synthesized molecules were evaluated as trypsin, lipoxygenase and lipid peroxidation inhibitors and for their cytotoxicity. Compound 2b derived from phenoxyphenyl cinnamic acid and propra...
متن کاملAntiviral activity of cholesteryl esters of cinnamic acid derivatives.
Cholesteryl 3",4"-dimethoxycinnamate (7) and a new synthesized o-coumaroyl ester of 3 beta-(2'-hydroxyethoxy)-cholest-5-en (13) exhibited a marked activity against poliovirus type 1 (Mahoney). Compound 7 showed an approximately 20-fold greater selectivity in its antiviral activity than compound 13. These compounds were selected from thirteen steryl esters of cinnamic acid derivatives through an...
متن کامل155 - Sedative-Hypnotic Agents
Barbiturates were formerly the primary sedative-hypnotic agents used clinically. Currently, they are most often encountered as anticonvulsants, induction agents for anesthesia, and agents used for procedural sedation. Because the barbiturates have largely been replaced clinically by benzodiazepines due to safety concerns, their prevalence in overdoses has drastically decreased when compared wit...
متن کاملSedative-Hypnotic Activity of Extracts and Essential Oil of Coriander Seeds
Background: Coriandrum sativum L. has been recommended for relief of insomnia in Iranian traditional medicine. However, no pharmacological studies have yet evaluated its sedative effects. The aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (10...
متن کاملNaturally Occurring Cinnamic Acid Sugar Ester Derivatives.
Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the i...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1981
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)54736-9