Secretin: specific binding to rat brain membranes
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چکیده
منابع مشابه
Secretin: specific binding to rat brain membranes.
The binding of [125I]secretin to rat brain membranes was investigated. Radiolabeled secretin bound with high affinity (KD = 0.2 nM) to a single class of noninteracting sites. Binding was specific, saturable, and reversible. Regional distribution studies indicated that the specific binding was greatest in the cerebellum, intermediate in the cortex, thalamus, striatum, hippocampus, and hypothalam...
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The binding of a radiolabeled bomebesin analogue to rat brain membranes was studied. [125I-Tyr4]Bombesin bound with high affinity (KD = 3 nM) to a single class of non-interacting sites. Binding was specific, saturable (3.8 pmol of sites/g of wet tissue), and reversible. Regional and subcellular distribution studies showed that the density of sites was 7-fold greater in the hippocampus than the ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1983
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.03-08-01620.1983