Second Virial Coefficients as Determined using Self Interaction Chromatography and Protein Aggregation in Solution
نویسندگان
چکیده
منابع مشابه
Second virial coefficient studies of cosolvent-induced protein self-interaction.
Protein self-interaction is important in protein crystal growth, solubilization, and aggregation, both in vitro and in vivo, as with protein misfolding diseases, such as Alzheimer's. Although second virial coefficient studies can supply invaluable quantitative information, their emergence as a systematic approach to evaluating protein self-interaction has been slowed by the limitations of tradi...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.2419