Second-order interactions with the treatment groups in controlled clinical trials
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Second-order interactions with the treatment groups in controlled clinical trials
The occurrence of significant second-order interactions for group characteristics was examined using real data in a randomized controlled trial (RCT). The interactions exist in all RCTs; they could be easily overlooked when using the simple randomization or stratification methods, but could become more obvious when minimization methods are used. Using real data from an RCT, the minimization met...
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ژورنال
عنوان ژورنال: Computer Methods and Programs in Biomedicine
سال: 2007
ISSN: 0169-2607
DOI: 10.1016/j.cmpb.2006.12.004