Sebestenoids A–D, BACE1 inhibitors from Cordia sebestena
نویسندگان
چکیده
منابع مشابه
Polymethoxyflavones: Novel β-Secretase (BACE1) Inhibitors from Citrus Peels
Beta-site amyloid precursor protein (APP) cleaving enzyme1 (BACE1) catalyzes the rate-limiting step of amyloid-β protein (Aβ) generation, and is considered as a prime target for Alzheimer's disease (AD). In search of a candidate for AD prevention, our efforts exploring the natural BACE1 inhibitor have led to the finding of nobiletin, tangeretin, and sinensetin-representative compounds of polyme...
متن کاملDevelopment and Structural Modification of BACE1 Inhibitors.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of β-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that β-secretase 1 (BACE1) plays an important role in the formation of β-amyloid. Discovery of new BACE1 inhibitors has become a significant method to s...
متن کاملCan brain impermeable BACE1 inhibitors serve as anti-CAA medicine?
BACKGROUND Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among the elderly and more frequently in patients with Alzheimer's disease (AD). CAA...
متن کاملSesquiterpenes and a phenylpropanoid from Cordia trichotoma.
Two new secondary metabolites, the phenylpropanoid 3-(2',4',5'-trimethoxyphenyl)propanoic acid (1) and the sesquiterpene (+)-1beta,4beta,6alpha-trihydroxyeudesmane (2) were isolated from the heartwood of Cordia trichotoma Vell., along with the known sesquiterpenes (-)-1beta,4beta,7alpha-trihydroxyeudesmane (3) and (+)-1beta,4beta,11-trihydroxyoppositane (4). Their structures were elucidated by ...
متن کاملAntioxidant Study Of Cordia Dichotoma
The present study was aimed at evaluating the antioxidant activities of Cordia dichotoma known for their medicinal properties in folk medicine. In an effort to reduce the undesirable consequences of synthetic food conservatives in human health and food industries, scientists have recently changed their interest to search new conservatives. Antioxidants are important inhibitors of lipid per-oxid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Phytochemistry
سال: 2010
ISSN: 0031-9422
DOI: 10.1016/j.phytochem.2010.09.008