Searching for a direct preparation of dihydropyrimidine-5-carboxamides under Biginelli reaction conditions
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چکیده
منابع مشابه
Ionic liquids catalyzed Biginelli reaction under solvent-free conditions
3,4-Dihydropyrimidin-2(1H)-ones were synthesised in high yields by one-pot three-component Biginelli condensation in the presence of room temperature ionic liquids such as 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMImBF4) or hexafluorophosphorate (BMImPF6) as catalysts under solvent-free and neutral conditions. © 2001 Elsevier Science Ltd. All rights reserved. Recently, the interest in ...
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Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind-Srogl reaction and Suzuki coupling to form biaryl-substituted dihydropyrimidinone, dihydropyrimidine, and thiazolopyrimidine compounds. The high efficiency...
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D-tartaric acid is successfully used as a green and efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions. The developed method has many advantages, including devoid of harmful catalyst and solvents, high yield and easily work-up.
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With the emergence of high-throughput screening in the pharmaceutical industry over a decade ago, synthetic chemists were faced with the challenge of preparing large collections of molecules to satisfy the demand for new screening compounds. The unique exploratory power of multicomponent reactions such as the Ugi four-component reaction was soon recognized to be extremely valuable to produce co...
متن کاملExperimentally designed optimized conditions for catalytic performance of nanostructured RuO2 in Biginelli reaction
Nanostructured RuO2 powders were synthesized via a hydrothermal method at 180 °C for 12 h using 1 and 2 M NaOH aqueous solutions. The structure of the obtained nanomaterials was investigated by powder X-ray diffraction (PXRD) technique. The morphology the obtained materials were studied by field emission scanning electron microscope (FESEM). The technique showed that with changing the reaction ...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2010
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0012.209