SDPS-23 CUMULATIVE TUMOR VOLUME THRESHOLD CORRELATES WITH NEUROCOGNITIVE IMPAIRMENT IN PATIENTS WITH NEWLY DIAGNOSED BRAIN METASTASES

Abstract OBJECTIVE To explore the basic situation of cognitive function in patients with initial state brain metastasis and potential factors affecting function, so as to find critical value cumulative tumor volume leading dysfunction. METHODS A total 284 who were newly diagnosed metastases underwent testing before radiotherapy Guangdong Sanjiu Brain Hospital from 2016 2022 retrospectively analyzed. The demographic information patients, KPS at time diagnosis, number metastases, volume, test data treatment organized. RESULTS impairment occurred 100/284 (the criteria for is that least two eight sub-tests are less than 1.5 standard deviation or one 2 deviations). Multivariate analysis showed tumors was not a factor Age, gender, KPS, educational level, risk function. cut-off MOCA, HVLT-R immediate memory, delayed VFT, TMT-A, TMT-B 13.608, 13.125, 11.070, 14.523, 11.113 cc, respectively, while SDMT TOL 5.435 4.528 respectively. CONCLUSIONS Before treatment, had no significant correlation but volume. involving overall dysfunction, memory speech decreased thinking speed between 11-14.5 threshold executive dysfunction computational 4.5-5.5 cc.