scVEGF Microbubble Ultrasound Contrast Agents

Microbubble ultrasound contrast agents: a review.

The superior scattering properties of gas bubbles compared with blood cells have made microbubble ultrasound contrast agents important tools in ultrasound diagnosis. Over the past 2 years they have become the focus of a wide and rapidly expanding field of research, with their benefits being repeatedly demonstrated, both in ultrasound image enhancement, and more recently in drug and gene deliver...

Advances in Ultrasound Mediated Gene Therapy Using Microbubble Contrast Agents

Microbubble ultrasound contrast agents have the potential to dramatically improve gene therapy treatments by enhancing the delivery of therapeutic DNA to malignant tissue. The physical response of microbubbles in an ultrasound field can mechanically perturb blood vessel walls and cell membranes, enhancing drug permeability into malignant tissue. In this review, we discuss literature that provid...

Nonlinear dynamics of lipid-shelled ultrasound microbubble contrast agents

Encapsulated gas microbubbles, known as contrast agents, are widely used in ultrasound medical applications. The present study is devoted to modelling of the spatio-temporal dynamics of lipid-shelled contrast agents. A theoretical model is proposed that describes the radial and translational motion of a lipid-shelled microbubble in an ultrasound field. The model approximates the behaviour of th...

Effect of ultrasound on adherent microbubble contrast agents.

An investigation into the effect of clinical ultrasound exposure on adherent microbubbles is described. A flow phantom was constructed in which targeted microbubbles were attached using biotin-streptavidin linkages. Microbubbles were insonated by broadband imaging pulses (centred at 2.25 MHz) over a range of pressures (peak negative pressure (PNP) = 60-375 kPa). Individual adherent bubbles were...

Molecular ultrasound imaging using microbubble contrast agents Paul