Screening of quorum sensing and biofilm inhibitors among pseudomonas aeruginosa clinical isolates

Quorum sensing (QS) is a process that enables bacteria to communicate using secreted small pheromone-like signaling molecules called autoinducers (AIs). This population of regulate gene expression collectively. These quorum systems regulates biofilm formation, virulence factors expression, bioluminescence, motility patterns, exopolysaccharide production, antifungal or antibiotic endoglucanase pigmentation, competence, plasmid conjugal transfer and cross-signaling between strains species. P. aeruginosa an important very dangerous opportunistic pathogen causing many fatal infections in patients with serious medical conditions. associated nosocomial mainly immunocompromised patients, it rated the third-most-common microorganism hospital-acquired representing about 10-15% recorded globally. Moreover, qRT-PCR revealed significant reduction genes inhibitors-treated comparison untreated bacteria. Virulence inhibitors could play role Pseudomonas sensing-dependent production such as therefore affect its pathogenesis host.