Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus

Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus.

Clavulanic acid is a β-lactam compound with potent inhibitory activity against β-lactamases. Studies have shown that certain amino acids play essential roles in CA biosynthesis. However, quantitative evaluations of the effects of these amino acids are still needed in order to improve CA production. Here, we report a study of the nutritional requirements of Streptomyces clavuligerus for CA produ...

متن کامل

Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus

Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

متن کامل

Enhancement of clavulanic acid production by mutant Streptomyces clavuligerus

β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...

متن کامل

Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus

Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

متن کامل

Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus

Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...

متن کامل

Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

منابع مشابه