Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
نویسندگان
چکیده
منابع مشابه
Screening for insulitis in adult autoantibody-positive organ donors.
Antibodies against islet cell antigens are used as predictive markers of type 1 diabetes, but it is unknown whether they reflect an ongoing autoimmune process in islet tissue. We investigated whether organs from adult donors that are positive for autoantibodies (aAbs) against islet cell antigens exhibit insulitis and/or a reduced beta-cell mass. Serum from 1,507 organ donors (age 25-60 years) w...
متن کاملGuidelines for potential multiple organ donors (adult). Part III: organ-specific recommendations.
Brain death (BD) alters the pathophysiology of patients and may damage the kidneys, the lungs, the heart and the liver. To obtain better quality transplant organs, intensive care physicians in charge of the maintenance of deceased donors should attentively monitor these organs. Careful hemodynamic, ventilatory and bronchial clearance management minimizes the loss of kidneys and lungs. The evalu...
متن کاملThe referral frequency of blood donors positive in HIV, HBV, and HCV screening tests after being called for and reasons for their non-return
Abstract Background and Objectives Informing and counseling donors with positive Transfusion Transmitted Infection (TTI) is essential for preventing them from donating blood in future, and starting treatment for reducing complications. So, we evaluated the referral of reactive donors. Materials and Methods This cross sectional study was conducted in Sh...
متن کاملScreening Donors for Xenotransplantation
Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following allotransplantation. Thus the prospect of xenotransplantation raises the issue of xenozoonoses-i.e., the transmission of animal infections to the human host. An...
متن کاملPupil diameter for confirmation of brain death in adult organ donors in Japan
Aim The criteria for brain death in Japan include a bilateral pupil diameter of ≥4 mm. We evaluated the appropriateness of a 4-mm pupil diameter in adult brain-dead donors in Japan. Methods We retrospectively reviewed the records of 148 consecutive adult brain-dead donors with an average age of 46 years. All records were anonymously registered to the Japanese Ministry of Health, Labour and We...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 2007
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db07-0416