Sclerostin Antibody–Induced Changes in Bone Mass Are Site Specific in Developing Crania
نویسندگان
چکیده
منابع مشابه
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چکیده زبان سیستم کاملی ازقوانین است که برای ایجاد ارتباط و تبادل معانی مورد استفاده قرار می گیرد که در رابطه تنگاتنگ با روابط قدرتی افراد می باشد. این رابطه و قدرت افراد می تواند مستقیما در انتخاب ضمایر و سایر ساختارهای زبانی حتی در رفتار افراد تاثیرگذار باشد. در هرجامعه ای ، تقریبا نوعی روابط قدرتی درمیان افراد موجود می باشد و این رابطه درنحوه ی استفاده ی آنها در زبان منعکس می شود. بررسی ای...
15 صفحه اولSclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength of Intact Bones in Adult Male Rats
We investigated the systemic effect of sclerostin monoclonal antibody (Scl-Ab) treatment on intact non-operated bones in an open osteotomy male Sprague Dawley (SD) rat model. Six-month-old male SD rats were subjected to transverse osteotomy at the right femur mid-shaft. Rats were injected subcutaneously with vehicle or Scl-Ab (25 mg/kg, 2 times per week) treatment for 9 weeks. Compared with veh...
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CONTEXT The role and importance of circulating sclerostin is poorly understood. High bone mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM due to other causes is unknown. OBJECTIVE Our objective was to determine circulating sclerostin concentrations in HBM. DESIGN AND PARTICIPAN...
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Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently no information on the relation of circulating sclerostin levels to age, gender, or bone mass in humans. Thus we measured serum sclerostin levels in a population-based sample of 362 women [123 premenopausal, 152 postmenopausal not on estrogen treatment (ET), and 87 postmenopausal on ET] and 318 men,...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2019
ISSN: 0884-0431,1523-4681
DOI: 10.1002/jbmr.3858