Scientists find gene linking inherited breast and ovarian cancer to non-inherited cases
نویسندگان
چکیده
منابع مشابه
Gene expression in inherited breast cancer.
Large proportions of hereditary breast cancers are due to mutations in the two breast cancer susceptibility genes BRCA1 and BRCA2. Considerable effort has gone into studying the function(s) of these tumor suppressor genes, both in attempts to better understand why individuals with these inherited mutations acquire breast (and ovarian) cancer and to potentially develop better treatment strategie...
متن کاملInherited Breast Cancer
During an eight-year period (January 1991– anuary 1999) a total of 11,200 women were xamined at the breast out-patient Department of he University Hospital. Of these, 7,750 were registered for the first time and 3,450 repeated their visit for different reasons. Of the 7,750 women, breast cancer was diagnosed in 261, who were treated appropriately. Out of the 261 breast cancer patients 9 (3.44%)...
متن کاملPromoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer.
The partner and localizer of BRCA2 (PALB2) gene was recently identified as a BRCA2-interacting protein and subsequently shown to be a Fanconi anemia gene (FANCN). Disease-associated point mutations resulting in protein truncation have been found in BRCA1/2 mutation-negative breast cancer families identifying PALB2 as a susceptibility gene for breast cancer. Aberrant promoter hypermethylation is...
متن کاملPolygenic inherited predisposition to breast cancer.
The known breast cancer predisposing genes account for only about 20% of inherited susceptibility. Epidemiological analyses suggest that much of the remaining 80% is explained by the combined effect of many individually weak genetic variants, rather than by further rare, highly penetrant mutations. In the near term, identification of variants may indicate new pathways or mechanisms in breast ca...
متن کاملInherited determinants of ovarian cancer survival.
PURPOSE Due to variation of outcome among cases, we sought to examine whether overall survival in ovarian cancer was associated with common inherited variants in 227 candidate genes from ovarian cancer-related pathways including angiogenesis, inflammation, detoxification, glycosylation, one-carbon transfer, apoptosis, cell cycle regulation, and cellular senescence. EXPERIMENTAL DESIGN Blood s...
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ژورنال
عنوان ژورنال: BMJ
سال: 2003
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.327.7426.1247-a