scHLAcount: allele-specific HLA expression from single-cell gene expression data

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Allele-specific gene expression uncovered.

Genetic variation in populations can result in variation in levels of gene expression but the extent to which this occurs has been unclear. In this article, recent studies of allele-specific expression among autosomal non-imprinted genes are reviewed. These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly co...

متن کامل

Gene expression Assessing allele-specific expression across multiple tissues from RNA-seq read data

Motivation: RNA sequencing enables allele-specific expression (ASE) studies that complement standard genotype expression studies for common variants and, importantly, also allow measuring the regulatory impact of rare variants. The Genotype-Tissue Expression (GTEx) project is collecting RNA-seq data on multiple tissues of a same set of individuals and novel methods are required for the analysis...

متن کامل

Gene Expression Deconvolution with Single-cell Data

Current in vitro methods for deriving pre-somitic mesoderm have an efficiency of less than 1% indicating an insufficient understanding of mammalian mesodermal differentiation. Here we present an initial look at an approach that augments current digital deconvolution algorithms with single-cell resolution data to derive a better characterization of the transcriptional profiles of cell-types in t...

متن کامل

Inference of allele specific expression levels from RNA-Seq data

Accurate allele specific expression estimation requires the availability of a diploid transcriptome, which makes it a challenging problem. Most existing methods rely on simple counting of alleles coverage at heterozygous Single Nucleotide Polymorphic sites. In this work, we present RNA-PhASE, a pipeline for Allele Specific gene and isoform Expression estimation from RNA-Seq Reads. The pipeline ...

متن کامل

Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data

Many genes are expressed in bursts, which can contribute to cell-to-cell heterogeneity. It is now possible to measure this heterogeneity with high throughput single cell gene expression assays (single cell qPCR and RNA-seq). These experimental approaches generate gene expression distributions which can be used to estimate the kinetic parameters of gene expression bursting, namely the rate that ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Bioinformatics

سال: 2020

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btaa264