Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
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چکیده
منابع مشابه
Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition.
Schizophrenia is associated with severe cognitive deficits, including impaired working memory (WM). A neural mechanism that may contribute to WM impairment is the disruption in excitation-inhibition (E/I) balance in cortical microcircuits. It remains unknown, however, how these alterations map onto quantifiable behavioral deficits in patients. Based on predictions from a validated microcircuit ...
متن کاملLinking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model.
Excitation-inhibition balance (E/I balance) is a fundamental property of cortical microcircuitry. Disruption of E/I balance in prefrontal cortex is hypothesized to underlie cognitive deficits observed in neuropsychiatric illnesses such as schizophrenia. To elucidate the link between these phenomena, we incorporated synaptic disinhibition, via N-methyl-D-aspartate receptor perturbation on intern...
متن کاملFEATURE ARTICLE Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model
Department of Physics, Yale University, New Haven, CT 06520, USA, Department of Neurobiology, Kavli Institute of Neuroscience, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Center for the Translational Neuroscience of Alcoholism (CTNA), Department of Psychiatry, Abraham Ribicoff Research Facili...
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متن کاملA computational model for spatial working memory deficits in schizophrenia.
Cognitive deficits in schizophrenia have been hypothesized to be caused by altered synaptic transmission in circuits of the prefrontal cortex. 2 main hypotheses have been put forward: reduced inhibition and hypofunctional NMDA receptors. Recently, Lee et al. (2008) found that spatial working memory deficits in schizophrenic patients include a disproportionately high incidence of high-confidence...
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ژورنال
عنوان ژورنال: Schizophrenia Research
سال: 2017
ISSN: 0920-9964
DOI: 10.1016/j.schres.2016.10.011