Schistosoma mansoniα1,3-fucosyltransferase-F generates the Lewis X antigen
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چکیده
منابع مشابه
Schistosoma mansoni α1,3-fucosyltransferase-F generates the Lewis X antigen.
Genetic evidence suggests that the Schistosoma mansoni genome contains six genes that encode α1,3-fucosyltransferases (smFuTs). To date, the activities and specificities of these putative fucosyltransferases are unknown. As Schistosoma express a variety of fucosylated glycans, including the Lewis X antigen Galβ1-4(Fucα1-3)GlcNAcβ-R, it is likely that this family of genes encode enzymes that are...
متن کاملAnalysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals.
The expression of Lewis fucosyltransferase (FT) mRNA was examined in gastric mucosa from two Lewis-positive [Le(+)] and two Lewis-negative [Le(-)] individuals. Northern blot analysis demonstrated that levels of mRNA were similar in both Le(+) and Le(-) gastric mucosa. We isolated the protein-coding region of the Lewis FT cDNA from Le(+) and Le(-) gastric mucosa by polymerase chain reaction (PCR...
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Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-react with the repeating L(ex) units on the surface of granulocytes. Consequently...
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We study the behavior of two maps in an effort to better understand the stability of ωlimit sets ω(x, f ) as we perturb either x or f , or both. The first map is the set-valued function Λ taking f in C(I ,I) to its collection of ω-limit points Λ( f ) = ⋃x∈I ω(x, f ), and the second is the map Ω taking f in C(I ,I) to its collection of ω-limit sets Ω( f )= {ω(x, f ) : x ∈ I}.We characterize thos...
متن کاملThe dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x.
Schistosoma mansoni soluble egg antigens (SEAs) are crucially involved in modulating the host immune response to infection by S. mansoni. We report that human dendritic cells bind SEAs through the C-type lectin dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN). Monoclonal antibodies against the carbohydrate antigens Lewisx (Lex) and GalNAcbeta1-4(Fucalpha1-3)GlcNAc (LDNF) inhibit bi...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2015
ISSN: 0959-6658,1460-2423
DOI: 10.1093/glycob/cwv103