Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.
نویسندگان
چکیده
منابع مشابه
Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable.
Scatter factor, a stimulant of epithelial cell motility, and Hepatocyte Growth Factor (HGF) were compared by cross-biological studies using naturally occurring and recombinant proteins in four bioassays. Both scatter factor and HGF produced similar effects in cell motility and DNA synthesis assays. Antibodies to scatter factor or HGF neutralized the biological activities of each cytokine, and i...
متن کاملNeoexpression of the c-met/hepatocyte growth factor-scatter factor receptor gene in activated monocytes.
Hepatocyte growth factor-scatter factor (HGF-SF ) mediates mito-, moto-, and morphogenic effects through the MET receptor, a membrane bound tyrosine kinase. HGF-SF/MET signaling is mitogenic for a large number of epithelial and endothelial cells and activates organ regeneration. HGF-SF transcripts have been detected in various myeloid cell lines. Therefore, the potential role of HGF-SF/MET sign...
متن کاملHepatocyte Growth Factor/Scatter Factor Effects
Intestinal epithelial cells rest on a fibroblast sheath. Thus, factors produced by these fibroblasts may influence epithelial function in a paracrine fashion. We examined modulation of intestinal epithelial function by one such fibroblast product, scatter factor/ hepatocyte growth factor (HGF/SF). This effect was studied in vitro by using model T84 intestinal epithelial cells. When applied to c...
متن کاملRoles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several fibroblast lines, may elicit morphogenesis in adjacent epithelial cells. We investigated the role of HGF/SF and its membrane receptor, the product of the c-met protooncogene, in the early development of the metanephric kidney. At the inception of ...
متن کاملScatter factor and its relationship to hepatocyte growth factor and met.
In the mid-1980s, Stoker and colleagues (1-3) described SF,2 a fibroblast-derived protein activity which disperses cohesive epithelial colonies. In the late 1980s, several groups characterized plateletand serum-derived proteins which stimulate hepatocyte DNA synthesis. These factors were called HCFs (4, 5), hepatopoietin A (6), and hepatotropin (7). In 1984, Cooper et a!. (8) described met, a t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1991
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1991.tb07836.x