Sıçanlarda pseudomonas aeruginosa ile indüklenen kronik otitis media modelinde borik asit tedavisinin etkinliği

Purpose: Chronic otitis media (COM) is one of the common infectious diseases middle ear caused by bacterial or viral pathogens. The purpose present study was to investigate efficacy boric acid (BA) in treatment COM comparing topical 4% and 8% BA applications with systemic ciprofloxacin a Pseudomonas aeruginosa (P. aeruginosa) inoculation-induced model rats.
 Materials Methods: Forty-two Sprague Dawley rats were divided into seven equal groups. created P. aeruginosa. Clinical, histopathological and, immunohistochemical comparisons performed between control, COM, treatment, contact groups.
 Results: In model, moderate edema, inflammation, degeneration tumor necrosis factor-alpha (TNF-α) expression detected application BA. Mild degeneration, mild TNF-α application.
 Conclusion: Both provided significant clinical, improvement. found exhibit greater therapeutic efficacy, no harmful effect on mucosa.