Scaffold Modifications in Erythromycin Macrolide Antibiotics. A Chemical Minireview
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چکیده
منابع مشابه
Macrolide antibiotics Azithromycin Azaerythromycin Clarithromycin Erythromycin Roxithromycin
Aminoglycosides Amikacin Framycetin Sulphate Gentamicin Sulphate Kanamycin Sulphate Lincomycin Neomycin Spectinomycin Tobramycin PET imaging tracer FDG Macrolide antibiotics Azithromycin Azaerythromycin Clarithromycin Erythromycin Roxithromycin Bioanalysis of pharmaceutics Acetaminophen Artemisinin Dihydro-artemisinin Artemether Etoposide 8-OH-DPAT mesna BNP7787 Vincristine Application Note Bio...
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Transformation of erythronolide B to new antibiotics was attempted by feeding this compound during the fermentation of Streptomyces antibioticus ATCC31771, a blocked mutant of an oleandomycin producing strain. As a result, four new active compounds were obtained with hybrid structures between erythromycin and oleandomycin. They were identified as 3-O-oleandrosyl-5-O-desosaminyl-15-hydroxyerythr...
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We examined the effects of sub-MICs of erythromycin (EM) and other macrolide antibiotics on the serum sensitivity of Pseudomonas aeruginosa. P. aeruginosa S-6 grown for 36 and 48 h on agar with 10 micrograms of EM per ml (1/10th the MIC) showed significantly increased sensitivity to human serum bactericidal activity compared with those of bacteria grown on agar without EM (P < 0.05). No changes...
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Since 1950, well over fifty macrolides have been derived from various Actinomycetes in screening laboratories located at many corners of the world. Among the most intensely studied macrolides are those produced on a commercial scale (erythromycin, oleandomycin, tylosin, leucomycin and spiramycin) as well as examples of particular historical/scientific importance (Magnamycin, pikromycin, narbomy...
متن کاملThe polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25173941