Satiation or satiety? More than mere semantics

We read with interest the excellent Series paper by Alexander Ford and colleagues1Ford AC Mahadeva S Carbone MF Lacy BE Talley NJ Functional dyspepsia.Lancet. 2020; 396: 1689-1702Summary Full Text PDF PubMed Scopus (41) Google Scholar describing epidemiology, pathophysiology, management of functional dyspepsia. commend authors for establishing a timely informative overview this disorder. colleagues use terms early satiety satiation interchangeably. In fact, Rome IV on gastroduodenal disorders does same, albeit symptom definition in diagnostic criteria refers specifically to satiation.2Stanghellini V Chan FK Hasler WL et al.Gastroduodenal disorders.Gastroenterology. 2016; 150: 1380-1392Summary (550) Early is also distinctive feature postprandial distress syndrome subtype dyspepsia, which characterised triggering or aggravation meal. However, we would like emphasise that, although regularly used as synonyms, are two different entities. Satiety feelings fullness between meals, whereas reflects during ingestion meal, acting terminating factor.3Camilleri M Peripheral mechanisms appetite regulation.Gastroenterology. 2015; 148: 1219-1233Summary (107) This distinction can be relevant it potentially underlying mechanisms. Meal nutrient volume-induced probably closely related gastric accommodation—ie, mechanosensory reaction proximal stomach. stomach not meaningfully detect composition feeling involves neurohormonal signals that originate from more distal parts gastrointestinal tract—ie, duodenum.4Janssen P Vanden Berghe Verschueren Lehmann A Depoortere I Tack J The role motility control food intake.Aliment Pharmacol Ther. 2011; 33: 880-894Crossref (201) Because heterogeneity disorder complexity its symptomatology, important clear consistent terminology support unravelling pathophysiological improve treatment outcomes. DK reports grants Will Pharma, Allergan, Grunenthal, ZonMw, Maag-Lever-Darmstichting, United Europe Gastroenterology, EU Horizon 2020, unrelated Correspondence. TK declares no competing interests. dyspepsiaDyspepsia complex symptoms referable region tract includes epigastric pain burning, fullness, satiety. Approximately 80% individuals dyspepsia have structural explanation their affects up 16% otherwise healthy general population. Risk factors include psychological comorbidity, acute gastroenteritis, female sex, smoking, non-steroidal anti-inflammatory drugs, Helicobacter pylori infection. Full-Text Satiation satiety? More than mere semantics – Authors' replyWe thank Tim Klaassen Daniel Keszthelyi our paper,1 pointing out these definitional issues. absence specific biomarker, consensus committee proposed descriptive definitions all individual dyspeptic enable evaluation, outcomes, patients.2 process ends an eating episode, therefore controlling meal size duration. mainly defined state non-hunger controls subsequent hunger intake.