منابع مشابه
Glutathione S-transferases Null Genotype in Acute Myeloid Leukaemia
Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...
متن کاملAssociation between acute myeloblastic leukaemia and sarcoidosis.
INTRODUCTION Sarcoidosis is a systemic granulomatous disorder thought to be an exaggerated immune response to unknown antigens. It often presents with bilateral mediastinal lymphadenopathy and/or pulmonary infiltrates (1). Sarcoidosis has been found in association with a variety of malignancies, including malignant myeloproliferative disorders (2). To date, only two cases of acute myeloblastic ...
متن کاملExpression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow
Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute m...
متن کاملAcute myeloid leukaemia in adults.
The outlook for patients with acute myeloid leukaemia has improved in the past 30 years. Unlike other cancers, much of this progress is attributable to refinement of supportive treatment, rather than the introduction of new drugs. New antibacterial and antifungal agents, antiemetics, and improved transfusion support have decreased the rate of early death, and morbidity and mortality from alloge...
متن کاملDiagnosis of Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a clonal, malignant disease of hematopoietic tissue characterized by accumulation of abnormal cells, mainly leukaemic blasts in bone marrow and impaired production of normal hematopoietic cells. Leukaemia was discovered in 1845, roughly at the same time by two doctors, Rudolph Virchow, a young Berlin pathologist and a Scottish pathologist, John Hughes Bennett. T...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1991
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689108400620