Saponin Interactions with Model Membrane Systems – Langmuir Monolayer Studies, Hemolysis and Formation of ISCOMs
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چکیده
منابع مشابه
Saponin Interactions with Model Membrane Systems - Langmuir Monolayer Studies, Hemolysis and Formation of ISCOMs.
Saponins are used in medicine due to their pharmacological and immunological effects. To better understand interactions of saponins with model membranes and natural membranes of, for example, erythrocytes, Langmuir film balance experiments are well established. For most saponins, a strong interaction with cholesterol was demonstrated in dependence of both the aglycone part and the sugar moietie...
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Structure of Membrane Holes in Osmotic and Saponin Hemolysis
Serial section electron microscopy of hemolysing erythrocytes (fixed at 12 s after the onset of osmotic hemolysis) revealed long slits and holes in the membrane, extending to around 1 microm in length. Many but not all of the slits and holes (about 100-1000 A wide) were confluent with one another. Ferritin and colloidal gold (added after fixation) only permeated those cells containing membrane ...
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We report the synthesis of monodisperse Pt nanocrystals with three different shapes-cubes, cuboctahedra, and octahedra, selectively, with similar sizes of 9-10 nm by a modified polyol process. We found that addition of silver ion enhances the crystal growth rate along 100, and essentially determines the shape and surface structure of the Pt nanocrystals. After the reaction, the silver species c...
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Cardiolipin (CL) is a complex phospholipid that is specifically found in mitochondria. Owing to the association of the CL levels with mitochondrial physiopathology such as in Parkinson's disease, we study the molecular effect of CL on membrane organization using model Langmuir monolayer, fluorescence microscopy, and x-ray reflectivity. We find that the liquid-expanded phase in membranes increas...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2016
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-0042-118387