منابع مشابه
Sanpodo seals precursors’ fate
Sanpodo seals precursors' fate D uring Drosophila development, sensory organ precursor (SOP) cells undergo a series of asym-metric divisions to generate mechanosen-sory bristles along the thorax of adult fl ies. Notch signaling controls the fate of the SOP cells' progeny, ensuring that each bristle contains a single neuron surrounded by hair, socket, and sheath cells. Upadhyay et al. describe h...
متن کاملNumb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs.
During asymmetric cell division in Drosophila sensory organ precursors (SOPs), the Numb protein segregates into one of the two daughter cells, in which it inhibits Notch signalling to specify pIIb cell fate. We show here that Numb acts in SOP cells by inducing the endocytosis of Sanpodo, a four-pass transmembrane protein that has previously been shown to regulate Notch signalling in the central...
متن کاملBetween Clotho and Lachesis: how isoflurane seals neuronal fate.
FOR more than 150 yr, general anesthetics have represented the quintessential triumph of medical pharmacology, providing painless oblivion for patients and a quiet field for surgeons. But now, concerns over long-term sequelae in the vulnerable brain have begun to tarnish the heretofore almost spotless image of general anesthetics. The extremely low therapeutic ratios of these powerful agents (w...
متن کاملSanpodo controls sensory organ precursor fate by directing Notch trafficking and binding γ-secretase
In Drosophila peripheral neurogenesis, Notch controls cell fates in sensory organ precursor (SOP) cells. SOPs undergo asymmetric cell division by segregating Numb, which inhibits Notch signaling, into the pIIb daughter cell after cytokinesis. In contrast, in the pIIa daughter cell, Notch is activated and requires Sanpodo, but its mechanism of action has not been elucidated. As Sanpodo is presen...
متن کاملMesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
In Drosophila, much has been learned about the specification of neuronal cell fates but little is known about the lineage of mesodermal cells with different developmental fates. Initially in development, individual mesodermal precursor cells are singled out to become the founder cells for specific muscles. The selection of muscle founder cells is thought to employ a Notch-mediated process of la...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2013
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2013if