Sample Size Requirements for Association Studies of Gene-Gene Interaction
نویسندگان
چکیده
منابع مشابه
Sample size requirements for association studies of gene-gene interaction.
In the study of complex diseases, it may be important to test hypotheses related to gene-gene (G x G) interaction. The success of such studies depends critically on obtaining adequate sample sizes. In this paper, the author investigates sample size requirements for studies of G x G interaction, focusing on four study designs: the matched-case-control design, the case-sibling design, the case-pa...
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BACKGROUND The search for interaction effects is common in epidemiological studies, but the power of such studies is a major concern. This is a practical issue as many future studies will wish to investigate potential gene-gene and gene-environment interactions and therefore need to be planned on the basis of appropriate sample size calculations. METHODS The underlying model considered in thi...
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Jimmy Thomas Efird, PhD, MSc; Mi-Kyung Hong, MPH The rates for diseases such as cancer, cardiovascular disease, and diabetes are known to differ by ethnic/racial groups. However, neither genetic nor environmental factors fully explain the observed differences. Failure to account for genetic expression in the absence or presence of an environmental factor, and vice-versa, may lead to erroneous c...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2002
ISSN: 0002-9262
DOI: 10.1093/aje/155.5.478