Sambiloto (Andrographis paniculata Nees.) leaf extract activity as an ?-Amylase enzyme inhibitor
نویسندگان
چکیده
Introduction: Sambiloto (Andrographis paniculata) is an antidiabetic medicinal plant that acts by inhibiting the ?-amylase enzyme. Andrographolide, active compound of sambiloto leaf, insoluble in water but dissolves ethanol. Aim: This study compared vitro activity aqueous extract and ethanolic leaf with Methods: The inhibitory test enzyme was carried out using ultraviolet-visible spectrophotometric method measuring absorbance remaining starch, which forms a blue complex iodine-iodide. Results: (with IC50 value 14.203 ± 0.112 mg/mL) lower than ethanol 9.253 0.116 mg/mL). results statistical tests showed significant differences (p <0.05) between acarbose both extracts.
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ژورنال
عنوان ژورنال: Pharmacy Education
سال: 2021
ISSN: ['1477-2701', '1560-2214']
DOI: https://doi.org/10.46542/pe.2021.212.305308