Salt, Salt Sensitivity, and the Endothelium
نویسندگان
چکیده
منابع مشابه
Salt and sensitivity.
A lmost 110 years ago, Ambard and Beaujard 1 were the first to systematically explore the association between salt intake and blood pressure. They start their article with the following statement (translated from French): " It seems to us that one can say that each individual who is able to retain chloride is, by that very fact, apt to develop arterial hypertension. " They go on by describing s...
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Accumulating evidence suggests that hypertension in blacks is manifested in part by impaired renal excretion of salt. Consequently, this study was performed to determine if hypertensive and normotensive black subjects differ in their ability to generate known natriuretic substances. Fourteen normotensive and 11 hypertensive blacks were maintained on constant metabolic diets containing either 40...
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The controversial issue of the relationship between dietary NaCl (referred to as “salt” in this article) intake and health was framed nicely in the superb review by Prof Eberhard Ritz.1 When salt was not readily available, it was a relatively essential commodity, but in the modern world salt has become plentiful, and it is actually difficult to achieve a low salt intake without exerting a signi...
متن کاملNeurogenic mechanisms and salt sensitivity.
The concept of salt sensitivity is based on the observation that some individuals respond to a high salt intake with a marked increase in blood pressure, whereas others experience little or no blood pressure changes. Salt sensitivity is found much more frequently in hypertensive than in normotensive subjects,1 and its presence predicts a significantly greater increase of blood pressure with age...
متن کاملIncreased dietary salt activates rat aortic endothelium.
The function of vascular endothelium as a biomechanical sensor permits alterations in gene expression in the vascular tree in response to wall stress. The present study explored the mechanism by which the arterial endothelium responds to changes in dietary salt. Normotensive rats were fed diets containing varying amounts of NaCl for 4 days. At that time, levels of phosphorylated p38 MAP kinase,...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2013
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.113.02085