Salmonella typhimurium aroA, htrA, and aroD htrA mutants cause progressive infections in athymic (nu/nu) BALB/c mice
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چکیده
منابع مشابه
Comparison of abilities of Salmonella enterica serovar typhimurium aroA aroD and aroA htrA mutants to act as live vectors.
We compared the ability of Salmonella enterica serovar Typhimurium SL1344 aroA aroD (BRD509) and aroA htrA (BRD807) mutants to act as live vectors for delivery of fragment C of tetanus toxin (FrgC). FrgC was expressed in these strains from either pTETnir15 or pTEThtrA1. BRD509FrgC(+) strains elicited approximately 2-log-higher serum anti-FrgC antibody titers than BRD807FrgC(+) strains. All mice...
متن کاملEffect of aroA, htrA and aroA-htrA Deletion Mutation on Ability of Salmonella Abortusequi to Survive and Multiply in Macrophages
To understand the problem of host specificity of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi), five isogenic strains including aroA, htrA and aroA-htrA deletion mutants, virulence plasmid cured and wild type parent strains were tested for invasion, survival and multiplication (up to 30 h) in cattle, goat, buffalo, horse and guinea pig macrophages and murine macro...
متن کاملHTRA 2 ( HtrA serine peptidase 2 )
Note Amplification of 2p13-16 has frequently been found in non-Hodgkin's lymphoma, mediastinal thymic B-cell lymphoma and in some cases of neuroblastoma, ovarian cancer, squamous cell carcinoma of the head and neck, non-small cell lung cancer and synovial sarcoma (Knuutila et al., 1998). Translocations and deletions of region 2p12 were found in acute and chronic lymphocytic leukaemias as well a...
متن کاملInfertility associated with sub clinical salmonellosis.
Subclinical infection of guinea pigs with isogenic wild type and aroA, htrA and aroA-htrA mutants of Salmonella enterica subspecies enterica serovar Abortusequi (S. Abortusequi) induced infertility, while mutants had little or no effect on conception rate in guinea pigs. Conception rate was significantly lower in guinea pigs inoculated with wild type (S-787) and aroA mutant of S. Abortusequi th...
متن کاملEffect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice.
DegQ is a serine protease that is highly homologous to HtrA, an important virulence determinant of Salmonella enterica serovar Typhimurium. We examined if DegQ is involved in serovar Typhimurium pathogenesis. A serovar Typhimurium degQ mutant was as virulent as the wild-type strain in mice. However, a serovar Typhimurium htrA degQ mutant survived less well in murine organs, particularly in the ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1997
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.65.4.1566-1569.1997