Salivary ACE2 and TMPRSS2 link to periodontal status and metabolic parameters

Background Periodontitis links extensively to various non-communicable diseases such as diabetes and cardiovascular disease most recently COVID-19 complications. Two important proteins in humans, ACE2 TMPRSS2, have been associated with health problems coronavirus infection. This study was investigate the soluble TMPRSS2 saliva serum well their association periodontal status systemic conditions. Methods The demographic background, lifestyles, full-mouth medical parameters 139 subjects were examined recorded. Saliva samples collected for determining levels of ACE2, MMP8. Findings salivary increased severity complexity periodontitis correlated positively alveolar bone loss MMP8 an inflammatory biomarker. While, negatively body mass index (BMI), cholesterol/high-density lipoprotein (HDL) ratio, low-density (LDL), number remaining teeth. No inter-correlation existed among both serum. Conclusions present demonstrated disparate correlation parameters. Salivary could differentiate severe periodontitis, while prominently linked metabolic obesity disease. Our findings imply potential application biofluidic form SARS-CoV-2 entry assessing oral or conditions delivering appropriate healthcare.