Safety of PPAR Agonists
نویسندگان
چکیده
منابع مشابه
Safety of PPAR Agonists
The thiazolidinediones pioglitazone and rosiglitazone were introduced into global markets in 1999–2000; we now have over 10 years of experience with them. The safety issues that it was fashionable to focus on at that time were abnormalities of liver function as a result of the rare but serious side effects of troglitazone, the thiazolidinedione then on the market. This turned out to be irrelave...
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Peroxisome proliferators activated receptors (PPARs) are ligand-activated nuclear transcription factors that play important roles in lipid and glucose homeostasis. To the extent that PPAR agonists improve diabetic dyslipidaemia and insulin resistance, these agents have been considered to reduce cardiovascular risk. However, data from murine models suggests that PPAR agonists also have independe...
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Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARalpha, PPARbeta/delta, and PPARgamma, regulate cell growth, morphogenesis, differentiation, and homeostasis. Agonists of each PPAR subtype exert their effects similarly or distinctly in different tissues such as liver, muscle, fat, and vessels. It is noteworthy that PPARalpha or PPARgamma...
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Lung cancer is the most common and most fatal of all malignancies worldwide. Furthermore, with more than half of all lung cancer patients presenting with distant metastases at the time of initial diagnosis, the overall prognosis for the disease is poor. There is thus a desperate need for new prevention and treatment strategies. Recently, a family of nuclear hormone receptors, the peroxisome pro...
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[Full Text] [Abstract] , January 1, 2004; 286 (1): E116-E122. Am J Physiol Endocrinol Metab A. R. Diani, G. Sawada, B. Wyse, F. T. Murray and M. Khan murine models of type 2 diabetes Pioglitazone preserves pancreatic islet structure and insulin secretory function in three [PDF] [Full Text] [Abstract] , March 1, 2005; 288 (3): E510-E518. Am J Physiol Endocrinol Metab F. Kawasaki, M. Matsuda, ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2011
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc11-s233