منابع مشابه
Side effects of cimetidine.
Cimetidine, an H2 receptor antagonist, is widely used in the treatment of duodenal ulcer, ZollingerEllison Syndrome (Binder et al., 1978; Winship, 1978; Ippoliti et al., 1978; Gray et al., 1978; Lc Canthy, 1978) benign gastric ulcer, gastric erosions and oesophagitis (Freston, 1979; Frost et al., 1977; Englert et al., 1978). In human beings it has a circulating half life of disappearance of 123...
متن کاملPostmarketing surveillance of the safety of cimetidine: 12 month mortality report.
A total of 9928 patients taking cimetidine and 9351 controls were recruited to a postmarketing drug surveillance study in Glasgow, Nottingham, Oxford, and Portsmouth. Takers were identified by the Prescription Pricing Bureau at Nottingham and by dispensing pharmacists at the other three centres. All but 1.2% of the takers and 1.6% of the controls were successfully followed up for one year durin...
متن کاملPostmarketing surveillance of the safety of cimetidine: 15-year mortality report.
The pattern of mortality after 15 years of observation is reported among almost 10,000 patients who were taking cimetidine when they were first recruited between 1977 and 1980. Many took the drug for a number of years, some switching to other antisecretory agents as the study progressed. The findings are reassuring and provide no evidence of any long-term adverse effects of cimetidine which mig...
متن کاملCimetidine and renal failure.
Introduction Cimetidine is a recently introduced but widely used histamine H2-antagonist. It is known to produce significant increases in plasma creatinine in normal people but the increased values usually remain in the normal range (Burland and Simkins, 1977). In clinical trials a tendency for plasma creatinine to rise, particularly in patients treated with high doses of cimetidine, was found ...
متن کاملGynaecomastia associated with cimetidine.
Gynaecomastia has occurred unilaterally or bilaterally in five out of 25 male duodenal ulcer patients after more than four months treatment with cimetidine 1.6 g daily. All elected to continue treatment to 12 months and their breast enlargement regressed rapidly and disappeared after stopping treatment. During treatment all patients were found to have normal concentrations of plasma testosteron...
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ژورنال
عنوان ژورنال: BMJ
سال: 1985
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.291.6506.1426-d