Safety of Benzathine Penicillin for Preventing Congenital Syphilis: A Systematic Review
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چکیده
منابع مشابه
Safety of Benzathine Penicillin for Preventing Congenital Syphilis: A Systematic Review
OBJECTIVE To estimate the risk of serious adverse reactions to benzathine penicillin in pregnant women for preventing congenital syphilis. METHODS We searched for clinical trials or cohorts that assessed the incidence of serious adverse reactions to benzathine penicillin in pregnant women and the general population (indirect evidence). MEDLINE, EMBASE, Scopus and other databases were searched...
متن کاملSingle-dose benzathine penicillin in infants at risk of congenital syphilis--results of a randomised study.
OBJECTIVE To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis. DESIGN Randomised study comparing benzathine penicillin with no therapy. SETTING Peninsula Maternal and Neonatal Service, Cape Town. SUBJECTS Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more. OUTCOME MEASURES The number of...
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Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...
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Arlene C. Seña, Mark Wolff, Frieda Behets, Kathleen Van Damme, David H. Martin, Peter Leone, Linda McNeil, and Edward W. Hook Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill; EMMES Corporation, Rockville, Maryland; Department of Epidemiology, University of North Carolina at Madagascar, Antananarivo; Department of Medicine, Louisiana State Uni...
متن کاملPractical Guidelines for Preventing Congenital Syphilis
A recent case of congenital syphilis at our hospital made us aware of the many potential pitfalls in the prevention of this disease. The patient in question presented in labor at term, and the intern noted a negative VDRL at the first prenatal visit. The attending physician on call (one of the authors) noted the low birth weight; however, the newborn had good Apgar scores and a normal cord pH. ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0056463