Safety data of Montanide ISA 51 VG and Montanide ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
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Safety data of Montanide ISA 51 VG and Montanide ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
Introduction Montanide ISA 51 VG and Montanide ISA 720 VG are two novel adjuvants dedicated to human therapeutic vaccines. They have been used in more than 200 clinical trials involving cancer, AIDS, malaria or autoimmune disease vaccines and involving an accrual of more than 20000 patients. The adjuvants are rendering stable water-in-oil emulsions when mixed with water based antigenic media. M...
متن کاملSustained release of actives with Montanide™ ISA 51 VG and Montanide™ ISA 720 VG, two adjuvants dedicated to human therapeutic vaccines
Introduction MontanideTM ISA 51 VG and MontanideTM ISA 720 VG are adjuvants dedicated to human therapeutic vaccines. The adjuvants are rendering stable water-in-oil (W/O) emulsions when mixed with water phase. In these formulations the active ingredients are entrapped in droplets of water surrounded by continuous oil phase. It allows a protection against degradation and slow release of the acti...
متن کاملEfficacy of Montanide ISA-70-VG as Adjuvant to Fowl Cholera Vaccine
Water in oil emulsion fowl cholera vaccine was prepared using Montanide ISA-70-VG oil as alternative adjuvant to the used white mineral oil with span-80. The two vaccines were comparatively evaluated in SPF chickens. Each vaccine was inoculated in a group of 40 chickens while the third group of 40 chickens was kept as non-vaccinated control. It was noticed that the Montanide ISA-70-VG formulate...
متن کاملEvaluation of Montanide™ ISA 71 VG Adjuvant during Profilin Vaccination against Experimental Coccidiosis
Chickens were immunized subcutaneously with an Eimeria recombinant profilin protein plus Montanide™ ISA 70 VG (ISA 70) or Montanide™ ISA 71 VG (ISA 71) water-in-oil adjuvants, or with profilin alone, and comparative RNA microarray hybridizations were performed to ascertain global transcriptome changes induced by profilin/ISA 70 vs. profilin alone and by profilin/ISA 71 vs. profilin alone. While...
متن کاملA vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis
BACKGROUND Schistosomiasis is the most important human helminth infection due to its impact on public health. The clinical manifestations are chronic and significantly decrease an individual's quality of life. Infected individuals suffer from long-term organ pathologies including fibrosis which eventually leads to organ failure. The development of a vaccine against this parasitic disease would ...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2015
ISSN: 2051-1426
DOI: 10.1186/2051-1426-3-s2-p428