Safety and Tolerability of Subcutaneous Cladribine Therapy in Progressive Multiple Sclerosis

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Safety and tolerability of subcutaneous cladribine therapy in progressive multiple sclerosis.

OBJECTIVE To evaluate the safety and tolerability of subcutaneous (s.c.) cladribine therapy in patients with chronic progressive multiple sclerosis (CPMS), and to evaluate the effects on lymphocyte subsets. BACKGROUND Cladribine, a synthetic antineoplastic agent with immunosuppressive effects, may favourably affect the course of CPMS. However results of a previous reported clinical trial show...

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Cladribine in the treatment of multiple sclerosis

ISSN 2041-6792 10.4155/CLI.10.32 © 2011 Future Science Ltd Treatment with cladribine leads to a preferential and sustained reduction in lymphocytes and monocytes, resulting in long-lasting depletion of CD4+ and CD8+ T cells. In the Phase III placebo-controlled trial in relapsing–remitting multiple sclerosis (the CLARITY study), oral cladribine at 96 weeks significantly reduced annual relapse ra...

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ژورنال

عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

سال: 1998

ISSN: 0317-1671,2057-0155

DOI: 10.1017/s0317167100034302