Safety and Immunological Outcomes Following Human Inoculation With Nontypeable Haemophilus influenzae
نویسندگان
چکیده
منابع مشابه
Safety and immunological outcomes following human inoculation with nontypeable Haemophilus influenzae.
BACKGROUND Nontypeable Haemophilus influenzae (NTHi) exclusively infects humans, causing significant numbers of upper respiratory tract infections. The goal of this study was to develop a safe experimental human model of NTHi nasopharyngeal colonization. METHODS A novel streptomycin-resistant strain of NTHi was developed, and 15 subjects were inoculated in an adaptive-design phase I trial to ...
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Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic dise...
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In this study we have investigated the ability of nonencapsulated, nontypeable Haemophilus influenzae, NT477 to survive in the J774 mouse macrophage-like cell line. Viable, intracellular nontypeable H. influenzae could still be recovered from macrophages 72 h after phagocytosis. In contrast, H. influenzae strain Rd, an avirulent, nonencapsulated variant of a serotype d strain, was killed within...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2013
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jit238