Safety and efficacy of nadifloxacin versus clindamycin observed in a tertiary care teaching hospital of Deccan Plateau

Acne vulgaris is characterised by excess sebum production and inflammatory reaction in sebaceous glands. As propionibacterium involved aggravation of acne, antimicrobials like nadifloxacin clindamycin were found to be effective treatment. Comparison with terms non-inflammatory lesion count global improvement rating, when given combination benzoyl peroxide patients acne Nadifloxacin 1%, 2.5% 1% used as topical treatment option. Study cohort was randomly divided into two groups: group Clindamycin group. All subjects who included the study instructed apply a thin layer medication over lesions; gel once daily at bedtime or twice daily. Efficacy analysed comparing changes total, counts, In addition, rated using six-point scale (worsening, no improvement, slight moderate good clearance) end There progressive decline number lesions both groups. Analysis counts not showed any significant difference between rating scale, more reported compared peroxide. No patient worsening lesions. None groups clearance. Two adverse events during study, they were, burning sensation dryness. incidence Topical Nadifloxacin, new fluoroquinolone effective, tolerable safe for mild facial acne. Its clinical effectiveness equivalent add-on therapy