S8. GRIN1 PROMOTER METHYLATION CHANGES IN BLOOD OF EARLY-ONSET PSYCHOTIC PATIENTS AND UNAFFECTED SIBLINGS WITH CHILDHOOD TRAUMA
نویسندگان
چکیده
منابع مشابه
comparison of blood flow velocity changes in posterior cerebral artery measured with transcranial doppler sonography in migraineurs with visual aura and normal persons after photostimulation
چکیده ندارد.
15 صفحه اولCognitive alterations in patients with non-affective psychotic disorder and their unaffected siblings and parents.
OBJECTIVE The purpose of this study was to examine a range of cognitive measures as candidate phenotypic liability markers for psychosis in a uniquely large sample of patients with psychosis, their unaffected relatives and control subjects. METHOD Patients with non-affective psychosis (n = 1093), their unaffected siblings (n = 1044), parents (n = 911), and controls (n = 587) completed a compr...
متن کاملDelayed white matter growth trajectory in young non - psychotic 1 siblings of childhood - onset schizophrenia patients
24 Context Non-psychotic siblings of childhood onset schizophrenia (COS) patients share 25 cortical gray matter (GM) abnormalities with their probands at an early age, that 26 normalize by the time siblings are 18 years old suggesting that the GM abnormalities in 27 schizophrenia could be an age-specific endophenotype. COS patients also show 28 significant white matter (WM) growth deficits whic...
متن کاملPCSK9 Associated Promoter Methylation Status in Patients with Hyperlipidemia
Background and purpose: Hyperlipidemia is one of the main risk factors for coronary artery disease and is defined as abnormal elevation of lipids or lipoproteins in the blood. Pcsk9 is the ninth member of the proprotein convertase family that binds to the LDLR on the surface of the hepatocyte, leading to degradation of LDLR in lysosomes which could cause hyperlipidemia. The present study aimed...
متن کاملGRIN1 Mutations in Early-Onset Epileptic Encephalopathy.
Investigators from Yokohama City University and other medical centers in Israel and Japan reported mutations on N-methyl-D-aspartate (NMDA) receptors subunit GRIN1 (GluN1) identified in patients with nonsyndromic intellectual disability and early-onset epileptic encephalopathy.
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2020
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbaa031.074