S18 Breast cancer and microRNAs: Therapeutic impact
نویسندگان
چکیده
منابع مشابه
Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications
Soon after the discovery of microRNAs over 15 years ago, a myriad of research groups around the world sought to develop clinical applications in breast cancer for these short, noncoding, regulatory RNAs. While little of this knowledge has translated into the clinic, the recent research explosion on cell-to-cell communication via exosomes and other extracellular vesicles has rekindled interest i...
متن کاملMicroRNAs and Breast Cancer
MicroRNAs are a class of small non-coding RNAs that are involved in the negative regulation of gene expression primarily through binding to the 3’untranslated region of their target mRNA. MicroRNAs have multiple mRNA targets, each of which can be regulated by multiple microRNAs making this a complex regulatory network. The identification of their importance in different types of cancer and vali...
متن کاملInherent radiosensitivity and its impact on breast cancer chemo-radiotherapy
About 10% of apparently normal individuals are sensitive to clastogenic effects of physico-chemical agents. More than 45% of breast cancer patients’ exhibit elevated radiosensitivity. Although the nature of inherent radiosensitivity is not fully understood, but insufficiency and impaired DNA repair mechanism might be prime cause of radiosensitivity. This is evident from genetically affect...
متن کاملMicroRNAs in the diagnosis and prognosis of breast cancer and their therapeutic potential (review).
MicroRNAs (miRNAs) are non-coding single-stranded RNAs in eukaryotes and are involved in the regulation of the post-transcriptional expression of specific genes. Studies have demonstrated that miRNAs play important roles in regulating diverse physiological events such as cell proliferation, differentiation and embryo development. In recent decades, considerable attention has been given to the r...
متن کاملIntracellular and extracellular microRNAs in breast cancer.
BACKGROUND Successful treatment of breast cancer is enhanced by early detection and, if possible, subsequent patient-tailored therapy. Toward this goal, it is essential to identify and understand the most relevant panels of biomarkers, some of which may also have relevance as therapeutic targets. METHODS We critically reviewed published literature on microRNAs (miRNAs) as relevant to breast c...
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ژورنال
عنوان ژورنال: The Breast
سال: 2011
ISSN: 0960-9776
DOI: 10.1016/s0960-9776(11)70021-2