S0486 Efficacy and Safety of Plecanatide in Patients With Chronic Idiopathic Constipation or Irritable Bowel Syndrome With Constipation: Intrinsic Factors Analyses From Four Studies

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Safety and efficacy of tegaserod therapy in patients with irritable bowel syndrome or chronic constipation.

BACKGROUND Tegaserod, a 5-HT4 agonist, is effective for treating irritable bowel syndrome and chronic constipation. However, sales of this drug were recently suspended due to concerns about a higher rate of cardiovascular events in patients receiving tegaserod over placebo in clinical trials. Our aim was to review patients in our practice prescribed tegaserod to determine if any of them had suf...

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Linaclotide (Linzess) for Irritable Bowel syndrome With Constipation and For Chronic Idiopathic Constipation.

Linaclotide (Linzess) for irritable bowel syndrome with constipation and for chronic idiopathic constipation.

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Lower and Upper Gastrointestinal Symptoms Differ Between Individuals With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation

Background/Aims We evaluated the distribution of lower and upper gastrointestinal (GI) symptoms among individuals with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in a nationwide survey. Methods Individuals (≥ 18 years of age) were identified from a nationwide sample of > 70 000 United States adults. Participants completed the National Institut...

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Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation

Background Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase III study evaluated the efficacy and safety of plecanatide versus placebo in CIC. Methods Adults meeting modified Rome III CIC criteria were rand...

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ژورنال

عنوان ژورنال: American Journal of Gastroenterology

سال: 2020

ISSN: 0002-9270,1572-0241

DOI: 10.14309/01.ajg.0000703992.84399.d3