S-Glutathionylation of metallothioneins by nitrosative/oxidative stress
نویسندگان
چکیده
منابع مشابه
Stress-induced protein S-glutathionylation in Arabidopsis.
S-Glutathionylation (thiolation) is a ubiquitous redox-sensitive and reversible modification of protein cysteinyl residues that can directly regulate their activity. While well established in animals, little is known about the formation and function of these mixed disulfides in plants. After labeling the intracellular glutathione pool with [35S]cysteine, suspension cultures of Arabidopsis (Arab...
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The KATP channels play an important role in the membrane excitability and vascular tone regulation. Previous studies indicate that the function of KATP channels is disrupted in oxidative stress seen in a variety of cardiovascular diseases, while the underlying mechanism remains unclear. Here, we demonstrate S-glutathionylation to be a modulation mechanism underlying the oxidant-mediated vascula...
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Mitochondria play an essential role in nitric oxide (NO) signal transduction in plants. Using the biotin-switch method in conjunction with nano-liquid chromatography and mass spectrometry, we identified 11 candidate proteins that were S-nitrosylated and/or glutathionylated in mitochondria of Arabidopsis (Arabidopsis thaliana) leaves. These included glycine decarboxylase complex (GDC), a key enz...
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The role of nitric oxide in several signalling routes has been clearly established. In recent years increasing attention has been paid to its ability to produce covalent protein post-translational modifications in conjunction with other reactive oxygen and nitrogen species. Among these, the modification of cysteine residues has been shown to be of particular importance due to the functional rel...
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Danyelle M. Townsend, Yefim Manevich, Lin He, Steven Hutchens, Christopher J. Pazoles, Kenneth D. Tew Departments of Pharmaceutical and Biomedical Sciences, Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 96 Johnathan Lucas St. P.O., Charleston, SC 29425 4 Novelos Inc., One Gateway Ctr, Newton, MA 02458. Running head: GSTπ catalyzes S-glutath...
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ژورنال
عنوان ژورنال: Experimental Gerontology
سال: 2008
ISSN: 0531-5565
DOI: 10.1016/j.exger.2007.11.004