S-adenosyl-L-methionine and the Cross-talk between the Bioenergetically Relevant Gasotransmitters H 2 S, NO and CO at Human Cystathionine β-synthase
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منابع مشابه
Development of methionine synthase, cystathionine-beta-synthase and S-adenosyl-homocysteine hydrolase during gestation in rats.
The developmental onset of three homocysteine metabolizing enzymes in the rat conceptus was investigated. Cystathionine-beta-synthase and methionine synthase were assayed from day 10 to day 20 of gestation in decidual and placental tissue, from day 10 to day 12 of gestation in embryonic tissue, from day 14 to day 20 of gestation in fetal liver and from day 14 to day 20 of gestation in fetal tis...
متن کاملThe enzymatic decomposition of S-adenosyl-L-methionine.
The role of S-adenosyl-n-methionine as a methyl donor has been investigated in mammalian systems (1) and in microbial metabolism (2-4). In addition, the compound is involved in the formation of spermidine from putrescine (5). Information concerning the stability of S-adenosylmethionine in various enzymatic systems is a necessary prerequisite for studies concerning its role in group transfer. In...
متن کاملDifferential expression of the S-adenosyl-L-methionine synthase genes during pea development.
Two genes coding for S-adenosyl-l-methionine synthase (SAMS, EC 2.5. 1.6) were previously isolated from pea (Pisum sativum) ovaries. Both SAMS genes were highly homologous throughout their coding regions but showed a certain degree of sequence divergence within the 5' and the 3' untranslated regions. These regions have been used as gene-specific probes to analyze the differential expression of ...
متن کاملBiosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Polyketides are among the major classes of bioactive natural products used to treat microbial infections, cancer, and other diseases. Here we describe a pathway to chloroethylmalonyl-CoA as a polyketide synthase building block in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity. S-adenosy...
متن کاملElicitor-Stimulated Furanocoumarin Biosynthesis in Cultured Parsley Cells: S-Adenosyl-L-Methionine:BergaptoI and S-Adenosyl-L-Methionine: Xanthotoxol O-Methyltransferases
Furanocoumarins, Phytoalexins, O-Methyltransferases, Fungal Elicitor, Cell Suspension Cultures Cultured parsley cells (Petroselinum crispum) treated with an elicitor from the soybean patho gen, Phytophthora megasperma f. sp. glycinea, were used as source for the separation, extensive purification and characterization of S-adenosyl-L-methionine: xanthotoxol and S-adenosyl-Lmethionine: bergaptol...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2016
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2016.04.334