(S)-4,5-Dihydro-2-(2-hydroxy-4-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic Acid Polyethers: A Solution to Nephrotoxicity
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چکیده
منابع مشابه
2-(4-Isopropyl-4-methyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)-5-methylnicotinic acid
In the title herbicideh/phytocide, known as imaza-pic, C(14)H(17)N(3)O(3), the pyridine and imidazole rings are almost coplanar [dihedral angle = 3.08 (5)°]. An intra-molecular O-H⋯N hydrogen bond occurs. In the crystal, an N-H⋯O hydrogen bond links mol-ecules into a chain parallel to [010].
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The title compound, C(10)H(11)NO(4)S, is of inter-est with respect to its biological activity. The mol-ecules are linked into centrosymmetric dimers by inter-molecular O-H⋯O hydrogen bonds and the dimers are further connected into chains by weak C-H⋯O inter-actions.
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The title compound, C(10)H(11)NO(5), is of inter-est with respect to its anti-dyslipidemic activity. It was prepared by reaction of 4-nitro-phenol with ethyl 2-bromo-2-methyl-propionate followed by ethyl ester hydrolysis. In the crystal, mol-ecules are linked into centrosymmetric dimers by inter-molecular O-H⋯O hydrogen bonds and the dimers are connected into chains by weak C-H⋯O inter-actions....
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In the title compound, C(12)H(16)N(2)O(6)S, the S atom adopts a distorted tetra-hedral geometry with an O-S-O angle of 119.76 (13)°. The nitro group is twisted by 35.34 (2)° with respect to the aromatic ring; it accepts an N-H⋯O hydrogen bond, resulting in a S(7) motif. In the crystal, N-H⋯O and O-H⋯O hydrogen bonds connect the mol-ecules into an infinite chain along the a axis. The methyl C at...
متن کامل2-Methyl-4-(2-methylbenzamido)benzoic acid
In the crystal structure of the title compound, C(16)H(15)NO(3), inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains parallel to the b axis and pairs of inter-molecular O-H⋯O hydrogen bonds between inversion-related carb-oxy-lic acid groups link the mol-ecules into dimers. The dihedral angle between the two benzene rings is 82.4 (2)°.
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2006
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm0508944