منابع مشابه
Autoimmune Inner Ear Disease- A Clinical Viewpoint
Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...
متن کاملAnalysis of gentamicin kinetics in fluids of the inner ear with round window administration.
HYPOTHESIS That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established. BACKGROUND As methods of local drug delivery to the inner ear gain wider clinical acceptance it becomes important to establish how drugs are distributed in the ear as a function of time and for different delivery methods. METHODS The time course of gentamicin co...
متن کاملPharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by Round Window Application
Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empiricallybased. As a result, consequences of changes in delivery method, applied drug concentration or even small alterations in treatment protocols have been difficult to predict. Since direct measurements of drug ...
متن کاملInside the inner ear
There are dozens of different myosin isozymes, though it's not clear why cells require such a diversity. These images of fluorescently-labelled hair cells from the inner ears of frog, guinea pig and mouse show the localization of actin (red at top left and bottom right) and of four different forms of myosin (green, except at bottom left, where myosin VI is labelled in red). Hair cells are the r...
متن کاملUnderstanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
Background The round window membrane (RWM) functions as the primary biological barrier for therapeutic agents in the inner ear via local application. Previous studies on inner ear nano-drug delivery systems mostly focused on their pharmacokinetics and distribution in the inner ear, but seldom on the interaction with the RWM. Clarifying the transport mechanism of nanoparticulate carriers across ...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1977
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.70.782