RUNX1 gene expression in Egyptian acute myeloid leukemia patients: may it have therapeutic implications?

Abstract Background Acute myeloid leukemia represents the highest percentage of all adult acute variants. Runt-related transcription factor1 ( RUNX1 ), a factor with known tumor suppressor function, was recently reported as promoter in (AML). We investigated role gene expression level Egyptian AML patients and delineated its clinical significance. Results measured using reverse transcription-quantitative polymerase chain reaction found that significantly higher than control group (p < 0.001). Patients FMS-like tyrosine kinase 3 internal tandem duplication FLT3 -ITD) mutations had = 0.023). The male expressed 0.046). Conclusions is highly patients. It has relation to FLT3-ITD, which may give clue carrying this mutation benefit from new treatments target future. Further studies on larger number different ethnic groups clearer vision therapeutic implications molecular target.