Runt Disease--I
نویسندگان
چکیده
منابع مشابه
Colonic manifestations of runt disease.
In view of the severe wasting and diarrhea in animals with runt disease, it is remarkable how little the intestinal tract of these animals has been studied. Observers have noted in the small bowel atrophy of Peyer's patches,"' slightly increased numbers of leucocytes in the mucosa`' and clubbing and bridging of villi in the ileum.' Thymectomized rats with runt disease have developed ulceration ...
متن کاملThe Production of Runt Disease in Rats Thymectomized at Birth
Thymectomy of Sprague-Dawley rats on the 3rd day of life failed to influence the time of onset, incidence, clinical, or histologic picture of runt disease produced by the intraperitoneal injection of adult Long-Evans spleen cells. The fact that severe immunologic impairment of the host by thymectomy does not modify runt disease was felt to be consistent with the current view that the if directi...
متن کاملAn Electron Microscope Study of Lymphatic Tissue in Runt Disease
The thymus, spleen, and lymph nodes were studied in runt disease induced by a graft of intravenously injected homologous splenic cells into newborn rats and mice. Adult Long-Evans cells (70 x 10(6)) were injected into Sprague-Dawley rats. Adult DBA cells (7 x 10(6)) were injected into C57BL/6 mice. Runted rats were sacrificed at 14 to 28 days of age; mice at 10 to 20 days. The thymic cortex is ...
متن کاملRunt Disease Induced in Neonatal Mice by Sterile Bacterial Vaccines
A form of runt disease has been produced in neonatal CF-1 and ICR mice by the repeated injection of 10(9) washed, autoclaved, saline-suspended staphylococci or streptococci. The most severely affected animals showed a marked decrease in lymphoid tissues and resembled grossly and microscopically animals suffering from the classical runt or wasting disease described by others. The timing of the i...
متن کاملMaternally Induced Transplantation Immunity, Tolerance, and Runt Disease in Rats
A previous report that the offspring of outbred Sprague-Dawley rats, born of mothers presensitized or tolerant with respect to tissue antigens of the Lewis strain, and reinoculated with Lewis cells during their pregnancy, reject test grafts of Lewis skin in an accelerated manner has been confirmed. This "maternally induced" alteration in reactivity of the progeny has been found to be long lasti...
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ژورنال
عنوان ژورنال: BMJ
سال: 1962
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5272.129